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Thursday, July 11, 2024

Nanorobot kills most cancers cells in mice with hidden weapon – NanoApps Medical – Official web site

Researchers at Karolinska Institutet in Sweden have developed nanorobots that kill most cancers cells in mice. The robotic’s weapon is hidden in a nanostructure and is uncovered solely within the tumor microenvironment, sparing wholesome cells. The examine is revealed within the journal Nature Nanotechnology.

The analysis group at Karolinska Institutet has beforehand developed constructions that may set up so-called loss of life receptors on the floor of cells, resulting in cell loss of life. The constructions exhibit six peptides (amino acid chains) assembled in a hexagonal sample.

“This hexagonal nanopattern of peptides turns into a deadly weapon,” explains Professor Björn Högberg on the Division of Medical Biochemistry and Biophysics, Karolinska Institutet, who led the examine.

“For those who have been to manage it as a drug, it could indiscriminately begin killing cells within the physique, which might not be good. To get round this downside, we’ve got hidden the weapon inside a nanostructure constructed from DNA.”

Created a ‘kill swap’

The artwork of constructing nanoscale constructions utilizing DNA as a constructing materials is known as DNA origami and is one thing Högberg’s analysis group has been engaged on for a few years. Now they’ve used the method to create a ‘kill swap’ that’s activated below the fitting circumstances.

“Now we have managed to cover the weapon in such a method that it could actually solely be uncovered within the setting present in and round a stable tumor,” he says. “Which means that we’ve got created a kind of nanorobot that may particularly goal and kill most cancers cells.”

The secret is the low pH, or acidic microenvironment that often surrounds most cancers cells, which prompts the nanorobot’s weapon. In cell analyses in check tubes, the researchers have been capable of present that the peptide weapon is hidden contained in the nanostructure at a traditional pH of seven.4, however that it has a drastic cell-killing impact when the pH drops to six.5.

Decreased tumor development

They then examined injecting the nanorobot into mice with breast most cancers tumors. This resulted in a 70 % discount in tumor development in comparison with mice given an inactive model of the nanorobot.

“We now want to analyze whether or not this works in additional superior most cancers fashions that extra carefully resemble the true human illness,” says the examine’s first writer Yang Wang, a researcher on the Division of Medical Biochemistry and Biophysics, Karolinska Institutet. “We additionally want to seek out out what negative effects the tactic has earlier than it may be examined on people.”

The researchers additionally plan to analyze whether or not it’s attainable to make the nanorobot extra focused by putting proteins or peptides on its floor that particularly bind to sure kinds of most cancers.

Extra info: A DNA Robotic Swap with Regulated Autonomous Show of Cytotoxic Ligand Nanopatterns, Nature Nanotechnology (2024). DOI: 10.1038/s41565-024-01676-4 , www.nature.com/articles/s41565-024-01676-4

Offered by Karolinska Institutet

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